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Circulating levels of GDNF in bipolar disorder |
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| Authors: | Barbosa Izabela Guimarães Huguet Rodrigo Barreto Sousa Lirlândia Pires Abreu Mery Natali Silva Rocha Natália Pessoa Bauer Moisés Evandro Carvalho Lívia A Teixeira Antônio Lúcio |
| Institution: | a Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil b Laboratório de Imunofarmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil c King's College London, Section and Laboratory of Stress, Psychiatry and Immunology (SPI-Lab), Division of Psychological Medicine, Institute of Psychiatry, UK d Departamento de Enfermagem Aplicada, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil e Laboratório de Imunologia, Pontifícia Católica Universidade do Rio Grande do Sul, Porto Alegre, Brazil f Psychoneuroimmunology Translational Lab, Roehampton University, London, UK |
| Abstract: | Neurotrophic factors regulate the survival and growth of neurons, and influence synaptic efficiency and plasticity. Several studies suggest the existence of a relationship between changes in neurotrophic levels and bipolar disorder (BD). The glial cell-line derived neurotrophic factor (GDNF) influences monoaminergic neurons and glial cells, but its role in BD patients is controversial. In order to elucidate it we evaluated plasma levels of GDNF in a sample of 70 BD patients (35 in mania and 35 in euthymia) and compared with 50 healthy controls matched for age, gender and educational levels. GDNF plasma levels were measured by enzyme-linked immunosorbent assay (ELISA). Patients were assessed by a Mini-International Neuropsychiatric Interview (MINI-plus), Young Mania and Hamilton Depression Rating Scales. Plasma GDNF levels were significantly increased in BD patients in euthymia compared with BD patients in mania and healthy controls (p < 0.05). GDNF plasma levels were correlated with age (ρ = 0.30, p < 0.05) and negatively correlated with manic symptoms in BD patients (ρ = −0.54, p < 0.05). Our results provide evidence that peripheral levels of GDNF are related with different mood states in BD, reinforcing the involvement of neurotrophic factors in its physiopathology. |
| Keywords: | BD bipolar disorder BDNF brain-derived neurotrophic factor DSM-IV-TR diagnostic and statistical manual of mental disorders text revision ELISA enzyme-linked immunosorbent assay GDNF glial cell-line derived neurotrophic factor HDRS Hamilton Depression Rating Scale MINI-Plus Mini-International Neuropsychiatric Interview YMRS Young Mania Rating Scale |
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