| 痹清胶囊对大鼠急性痛风性关节炎白细胞介素12及诱导型环氧化酶表达的影响 |
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| 引用本文： | 周敏,董娜,韩玉生,万丽鹤,杨伟鹏.痹清胶囊对大鼠急性痛风性关节炎白细胞介素12及诱导型环氧化酶表达的影响[J].中国实验方剂学杂志,2008,14(11):53-54. |
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| 作者姓名： | 周敏 董娜 韩玉生 万丽鹤 杨伟鹏 |
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| 作者单位： | 1. 黑龙江中医药大学,黑龙江,哈尔滨,150040
2. 中国中医科学院中药研究所,北京,100700 |
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| 摘 要： | 目的:采用尿酸钠(MUS)诱导的大鼠急性痛风性关节炎模型,研究痹清胶囊治疗急性痛风性关节炎作用机理。方法:采用ELISA方法测定踝关节液白细胞介素12(IL-12)的含量及采用免疫组化方法测定大鼠踝关节诱导型环氧化酶(COX-2)的表达。结果:痹清胶囊明显降低痛风性关节炎模型大鼠踝关节IL-12的含量、抑制大鼠踝关节COX-2的表达。结论:痹清胶囊治疗痛风性关节炎有确切疗效,可能与降低IL-12的含量、抑制COX-2的表达有关。
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| 关 键 词： | 痹清胶囊 尿酸钠 痛风性关节炎 白细胞介素12 诱导型环氧化酶 |
| 收稿时间： | 4/1/2008 12:00:00 AM |
Influence of Biqing Capsule on IL-12 and COX-2 Expression in Mouse with Acute Gouty Arthritis |
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| ZHOU Min,DONG N,HAN Yu-sheng,WAN Li-he,YANG Wei-peng.Influence of Biqing Capsule on IL-12 and COX-2 Expression in Mouse with Acute Gouty Arthritis[J].China Journal of Experimental Traditional Medical Formulae,2008,14(11):53-54. |
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| Authors: | ZHOU Min DONG N HAN Yu-sheng WAN Li-he YANG Wei-peng |
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| Institution: | 1.Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;2.Institute of China Materia,China Academy of China Medical Sciences,Beijing 100700,China |
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| Abstract: | Objective:By uric acid sodium(MUS)-induced acute gouty arthritis model,to observe Biqing Capsule treatment for acute gouty arthritis.Methods: The IL-12 content in joint fluid of ankle was measured by ELISA method.Mouse ankle COX-2 expression was determined by immunohistochemical methods.Results:Biqing Capsule obviously decreased ankle IL-12 levels and restrained rat ankle COX-2 expression.It indicated that Biqing Capsule for acute gouty arthritis had some anti-inflammatory effects.Conclusion: The Biqing Capsule's anti-inflammation and analgesia mechanism may be related to decreased ankle IL-12 level and restrained ankle COX-2 expression. |
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| Keywords: | Biqing Capsule MUS gouty arthritis IL-12 COX-2 |
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