Role of serum interleukin-18 as a prognostic factor in patients with hepatocellular carcinoma |
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Authors: | Tangkijvanich Pisit Thong-Ngam Duangporn Mahachai Varocha Theamboonlers Apiradee Poovorawan Yong |
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Affiliation: | 1. Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand 2. Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand 3. Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand 4. Center of Excellence in Viral Hepatitis Research, Department of Pediatrics,Faculty of Medicine, Chulalongkorn University, Bangkok 10330,Thailand |
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Abstract: | AIM: To determine whether serum interleukin-18 (IL-18) levels correlated with clinicopathologic features and prognosis in patients with hepatocellular carcinoma (HCC). METHODS: Serum IL-18, IL-6 and IL-12 levels were measured by enzyme-linked immunosorbent assay (ELISA) from 70 patients with HCC and 10 healthy controls. RESULTS: Serum IL-18, IL-6 and IL-12 levels of patients with HCC were significantly higher that those of the controls. The levels of IL-18 correlated significantly with the presence of venous invasion and advanced tumor stages classified by Okuda's criteria. Patients with high serum IL-18 levels (>= 10(5) pg/mL) had a poorer survival than those with low serum IL-18 levels (< 10(5) pg/mL) (4 and 11 mo, respectively, P = 0.015). Multivariate analyses showed that serum IL-18 level, but not IL-6 and IL-12 levels, was a significant and independent prognostic factor of survival. CONCLUSION: These findings demonstrate that serum IL-8 may a useful biological marker of tumor invasiveness and an independent prognostic factor of survival for patients with HCC. Thus, the detailed mechanisms of IL-18 involving in tumor progression should be further investigated. |
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Keywords: | Hepatocellular carcinoma Interleukin-18 Serum marker Prognosis |
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