Caveats of caveolin-1 in cancer progression |
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| Authors: | Burgermeister Elke Liscovitch Mordechai Röcken Christoph Schmid Roland M Ebert Matthias P A |
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| Affiliation: | Department of Medicine II, Klinikum rechts der Isar, Technical University of München, Ismaningerstrasse 22, D-81675 München, Germany. |
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| Abstract: | Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately gained recognition as a stage- and tissue-specific tumor modulator in vivo. Patient studies and rodent models corroborated its janus-faced role as a tumor suppressor in non-neoplastic tissue, its down-regulation (loss of function) upon transformation and its re-expression (regain of function) in advanced-stage metastatic and multidrug resistant tumors. This review is focussed on the role of caveolin-1 in metastasis and angiogenesis and its clinical implications as a prognostic marker in cancer progression. |
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| Keywords: | Cav-1, caveolin-1 KO, knock-out NOS, nitric oxide synthase NR, nuclear receptor MDR, multidrug resistance GI, gastrointestinal tract TJ, tight junction ZA, adherens junction ECM, extracellular matrix VSMC, vascular smooth muscle cells EC, endothelial cells MMP, matrix metalloproteases PDAC, pancreatic ductal adenocarcinoma GC, gastric adenocarcinoma CSD, Cav-1 scaffolding domain MAD, membrane attachment domain TMD, transmembrane domain |
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