大豆异黄酮对无菌小鼠脂代谢的影响

目的通过无菌(GF)小鼠模型研究大豆异黄酮(SI)对脂代谢的影响,探讨肠道菌群在大豆异黄酮调节脂代谢中的作用。方法用高脂饲料饲养GF小鼠,并选择低、中、高剂量SI对其进行干预,干预4周后,检测血液中血脂指标和抗氧化指标,称量肝脏、肠和心脏重量后进行比较。结果高脂饲料使GF小鼠血液中总胆固醇、甘油三酯水平升高,同时出现肝脏、肠重量增加,心脏重量减小,SI具有减小肠重量增加幅度和心脏重量降低幅度的保护作用。SI能提高高密度脂蛋白胆固醇(HDL-c)水平,但在GF小鼠实验中未见SI提升抗氧化功能的作用。结论 SI对高脂饮食下的心脏和肠道有保护作用,且能提高HDL-c,预防动脉粥样硬化的发生,提示SI对脂代谢的有益作用不完全依赖于其肠道菌群代谢产物雌马酚。

Influence of lipid metabolism of germ free mice' by soy isflavones

Objective To study the role of the intestinal floras in the effect of soy isflavones(SI) on lipid metabolism by germ free(GF) mice.Methods GF mice were fed by high fat diet and different doses of SI.After 4 weeks,the indexes of blood lipid and oxidation and weigh livers,intestines and hearts were tested.Results The weight of livers and intestines were increased,while the weight of hearts was decreased by feeding high fat diet to GF mice.But,SI can reduced the increase of intestine and decrease of heart.SI can also raise the level of HDL-c,while it can't improve antioxidant level.Conclusion SI can protect hearts and intestines from GF mice which were fed by fat lipid diets.SI also increases the level of HDL-c which is benefit of prevention of atherosclerosis.So the beneficial effects of SI not completely dependent on the equol which is produced by intestinal flora.