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肝癌细胞凋亡相关基因bcl—2及bax的表达意义
引用本文:任勇亚,李士瑛.肝癌细胞凋亡相关基因bcl—2及bax的表达意义[J].山西职工医学院学报,2001,11(1):1-2.
作者姓名:任勇亚  李士瑛
作者单位:1. 山西职工医学院,山西,太原,030012
2. 山西医科大学,山西,太原,030001
摘    要:目的:探讨凋亡抑制基因和凋亡促进基因bax表达与肝癌生物学行为的关系及对肝癌预后的关系。方法:用免疫组化LSAB法测定40例肝癌细胞和16例正常肝组织的bcl-2和bax蛋白表达水平。结果:bcl-2及bax蛋白表达率在正常肝组织及肝细胞分别为12.5%、45.0%、87.5%、52.5%,两组间差异有显著性(P<0.05)。bcl-1,bax蛋白表达与肿瘤病理分级、分期、淋巴结转移及患者预后相关,结论:bcl-2和bax蛋白的表达与了肝癌的发生及进展,并存在相互作用的关系.bcl-2蛋白表达在肝癌有独立预后价值。

关 键 词:肝细胞癌  细胞凋亡  癌基因  bcl-2
文章编号:1671-0126(2001)01-0001-02
修稿时间:2000年12月12

Expression of Apoptosis Related Gene Bcl - 2 and Bax in Liver Cell Carcinoma and Its Clinical Significances
REN Yong ya ,LI Shi ying.Expression of Apoptosis Related Gene Bcl - 2 and Bax in Liver Cell Carcinoma and Its Clinical Significances[J].Journal of Shanxi Medical College For Continuing Education,2001,11(1):1-2.
Authors:REN Yong ya  LI Shi ying
Institution:REN Yong ya 1,LI Shi ying 2
Abstract:Objective To study the role and the prognostic effect of bcl-2 (an apoptosis suppressing oncogene) and bax(an apoptosis accelerating oncogene)in the development of liver cell carcinoma.Methods Bcl-2 and bax expression was investigated in 40 cases of liver cell carcinoma and 16 cases of normal liver tissue by immunohistochemistry LSAB method.Results The positive rates of bcl-2 and bax expression were 12 5 %and 87 5 % in normal liver tissue and 45 0 %and 52 5 % in liver cell carcinoma.The difference was of significance ( P <0 05).Bcl-2 and bax expression levels were associated with histological grade stages,lymph node metastasis and prognosis.Conclusion The increased expression of bcl-2 and decreased expression bax might be involved in the devetopment of liver cell carcinoma,and they might have a mutual effect on each other.Bcl-2 protein is an independent indicator of prognosis in liver cell carcinoma.
Keywords:liver cell carcinoma  apoptosis  oncogene
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