Behavioural activity of rats measured by a new method based on the piezo-electric principle |
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Authors: | A A H P Megens J Voeten J Rombouts T F Meert C J E Niemegeers |
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Institution: | (1) Department of Pharmacology, Janssen Pharmaceutica, Turnhoutsebaan 30, B-2340 Beerse, Belgium |
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Abstract: | Spontaneous and drug-induced (haloperidol, apomorphine, and amphetamine) motor activity of rats was measured simultaneously via two distinct and independent methods: the classical optical scanning technique and a new procedure based on the piezo-electric principle. The latter procedure measured animal-induced mechanical vibrations of a flexible cage floor which were transduced into electric signals via piezo-electricity. The piezo method appeared to be relatively more sensitive in recording the small, stereotyped motor movements induced by apomorpine (0.63– 10 mg/kg) and high doses of amphetamine (2.5– 20 mg/kg). The optical scanning technique, on the other hand, was more sensitive in recording horizontal displacements across the cage such as induced by low doses of amphetamine (0.31–2.5 mg/kg). Both methods showed comparable sensitivity in recording the depression of behaviour induced by haloperidol (0.04– 1.25 mg/kg) or low doses of apomorphine (0.04–0.16 mg/kg). The piezo method may complement the optical scanning procedure, and thereby enhance the information on the extent that test compounds modify animal behaviour. |
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Keywords: | Motor activity Locomotion Behaviour Methods Haloperidol Apomorphine Amphetamine Rats |
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