| 冰片对大鼠不同脑区5-羟色胺合成及转运的影响 |
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| 引用本文： | 李伟荣,王宁生,宓穗卿.冰片对大鼠不同脑区5-羟色胺合成及转运的影响[J].时珍国医国药,2010,21(2). |
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| 作者姓名： | 李伟荣 王宁生 宓穗卿 |
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| 作者单位： | 广州中医药大学临床药理研究所,广东,广州,510405 |
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| 摘 要： | 目的 观察冰片对大鼠不同脑区5-羟色胺(5-HT)合成及转运的影响.方法 采用5-HT合成抑制剂对氯苯基丙氨酸(p-chlorophenylalanine, p-CPA)及5-HT再摄取抑制剂氟西汀(fluoxetine)作为工具药,以观察在合用冰片后对大鼠不同脑区5-HT含量的影响.结果 单用冰片组可升高大鼠下丘脑、脑干5-HT含量,单用p-CPA或与冰片合用均可明显降低大鼠各脑区5-HT含量,单用氟西汀可明显升高大鼠脑内5-HT含量,除下丘脑外均有显著性差异(P<0.05或P<0.01);氟西汀合用冰片亦可升高大鼠脑内5-HT含量,除海马外均有显著性差异(P<0.05或P<0.01).结论 冰片可升高大鼠下丘脑、脑干5-HT含量,与p-CPA、氟西汀合用后,不能改变此二者降低或升高脑内5-HT含量的作用趋势.
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| 关 键 词： | 冰片 对氯苯基丙氨酸 氟西汀 5-羟色胺 |
Effect of Borneol on Synthesis and Transmission of 5-HT in Rat Different Brain Region |
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| LI Wei-rong,WANG Ning-sheng,MI Sui-qing.Effect of Borneol on Synthesis and Transmission of 5-HT in Rat Different Brain Region[J].Lishizhen Medicine and Materia Medica Research,2010,21(2). |
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| Authors: | LI Wei-rong WANG Ning-sheng MI Sui-qing |
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| Institution: | LI Wei-rong,WANG Ning-sheng,MI Sui-qing(Institute of Clinical Pharmacology,Guangzhou University of Chinese Medicine,Guangzhou 510405,China) |
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| Abstract: | Objective To observe the effect of borneol on synthesis and transmission of 5-HT in rat different brain regions.Methods p-chlorophenylalanine(p-CPA),a synthesis inhibitor of 5-HT and fluoxetine,a reabsorbing blocker of 5-HT were adopted as tool drugs,to observe the effect of borneol on the content of 5-HT in different rat brain regions.Results Borneol could increase the contents of 5-HT in rat hypothalamus and brain stem.CPA or borneol could decrease the content of 5-HT in rat different brain regions.Fluoxe... |
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| Keywords: | Borneol p-Chlorophenylalanine(p-CPA) Fluoxetine 5-Hydroxytryptamime(5-HT) |
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