自身免疫性脑炎相关癫痫对儿童认知功能影响

目的：探讨自身免疫性脑炎相关癫痫对儿童认知功能的影响。方法选择2010年2月-2014年2月新乡市中心医院（以下简称“我院”）收治的自身免疫性脑炎引发癫痫患儿40例为病例组,序贯选择同期在我院行常规体检的健康儿童40名作为对照组。采用中国韦氏儿童智力量表及Halstead-Reita（H-R）儿童神经心理成套测验检测并比较两组儿童智商（IQ）及脑病损程度（DQ）。同时,收集病例组患儿一般情况,采用Logistic回归分析自身免疫性脑炎引发癫痫患儿智力的影响因素。结果病例组患儿智力主要处于低于平常（32.5%）及边界（40.0豫）水平,而对照组主要为平常（85.0豫）水平；病例组IQ值（72.7±21.8）分]低于对照组（98.2±8.7）分],差异有统计学意义（P〈0.05）。脑病损程度评价结果显示,病例组患儿DQ一般处于中度（62.5%）,而对照组主要处于正常脑功能（95.0%）水平；两组DQ值比较,病例组（0.51±0.13）]高于对照组（0.07±0.02）],差异有统计学意义（P〈0.05）。Logistic回归分析结果显示,发病频率、病程、抗癫痫药种类与自身免疫性脑炎引发癫痫患儿智力相关,且均为危险因素（OR 〉1,P〈0.05）。结论自身免疫性脑炎相关癫痫可降低儿童认知功能,其发生可能与发病频率、病程、抗癫痫药种类相关。

Influence of epilepsy induced by autoimmune encephalitis on cognitive function of children

Objective To discuss the influence of autoimmune encephalitis on cognitive function of children. Methods 40 children with epilepsy induced by autoimmune encephalitis treated in Central Hospital of Xinxiang City （“our hospi-tal” for short） from February 2010 to February 2014 weObjective To discuss the influence of autoimmune encephalitis on cognitive function of children. Methods 40 children with epilepsy induced by autoimmune encephalitis treated in Central Hospital of Xinxiang City （“our hospi-tal” for short） from February 2010 to February 2014 were selected as cases group, 40 health children with routine physical examination in our hospital in the same period were selected as control group sequentially. WISC-Ⅲ scale and Halstead-Reitan neuropsychological test battery for children were used for the detection of children＆#39;s IQ and brain damage （DQ）, and the results were compared between the two groups. While children＆#39;s general conditions were collect-ed in the cases group, Logistic regression analysis was used for discuss the influence factor of IQ in children with au-toimmune encephalitis induced epilepsy. Results The IQ of children in the cases group was in the level of lower than usual （32.5%） and boundary （40.0%）, which in the control group was in the level of usual （85.0%）. The IQ value in the cases group （72.7±21.8） scores] was significantly lower than that of the control group （98.2±8.7） scores], the difference was statistically significant （P〈0.05）. The DQ of children in the cases group was in the level of moderate （62.5%）, which in the control group was in the level of normal brain function （95.0%）. The DQ value in the cases group （0.51±0.13）] was significantly higher than that of the control group （0.07±0.02）], the difference was statistically significant （P〈0.05）. Lo-gistic regression analysis results showed that frequency of disease development, course of disease and types of antiepilep-tic drugs were related with