血清超敏-C 反应蛋白水平对糖尿病患者脑血管意外的预测价值

目的：探讨超敏C反应蛋白（hs-CRP）水平在糖尿病患者脑血管意外中的预测价值。方法选择2012年5月~2013年5月宜宾市第二人民医院南区治疗的2型糖尿病合并脑血管意外患者66例为脑血管意外组，选择同时期治疗的2型糖尿病未发生脑血管意外事件的患者66例为单纯糖尿病组，同期健康体检者66例为对照组。分别检测并比较三组的空腹血糖（FPG）、口服葡萄糖耐量试验（OGTT）以及hs-CRP浓度情况。结果①脑血管意外组、单纯糖尿病组FPG值[（8.53±2.03）、（8.62±1.35）mmol/L]、餐后2 h血糖（2 h PG）值[（13.89±2.27）、（14.19±1.86）mmol/L]均高于对照组[（4.01±1.10）、（6.17±1.71）mmol/L]，差异均有统计学意义（P〈0.05）；脑血管意外组、单纯糖尿病组之间FPG值、2 h PG值比较，差异无统计学意义（P〉0.05）。②三组间hs-CRP水平及异常比例比较，差异均有统计学意义（F=3.973，χ2=4.730，P〈0.05）；其中脑血管意外组hs-CRP水平[（12.58±3.53）μg/mL]高于单纯糖尿病组[（4.87±1.94）mg/L]及对照组[（2.03±0.71）mg/L]，差异有统计学意义（P〈0.05）；单纯糖尿病组hs-CRP水平高于对照组，差异有统计学意义（P〈0.05）。结论 hs-CRP对糖尿病合并脑血管意外具有明显的预测价值，可作为脑血管事件的预测因子。

Predictive value of serum hypersensitivity C-reactive protein in diabetes patients with cerebrovascular accident

Objective To investigate the predictive value of serum hypersensitivity C-reactive protein in diabetes pa-tients with cerebrovascular accident. Methods 66 cases of type 2 diabetes combined with cerebrovascular accident from Mau 2012 to May 2013 in the Southern District of the Second People＆#39;s Hospital of Yibin City were selected as cere-brovascular accident group, 66 cases of type 2 diabetes without cerebrovascular accident in the same term were chosen as simple diabetes group, 66 cases of healthy people were selected as control group. Fasting blood-glucose （FRG）, oral glucose tolerance test （OGTT）, hs-CRP level among the three groups were detected and compared. Results①The value of FPG, 2 h PG in cerebrovascular accident group [（8.53±2.03）, （13.89±2.27） mmol/L] and simple diabetes group [（8.62±1.35）, （14.19±1.86） mmol/L] were all higher than those in control group [（4.01±1.10）, （6.17±1.71） mmol/L], the differences were statistically significant （P〈0.05）. The differences of FPG, 2 h PG value between cerebrovascular ac-cident group and simple diabetes group were not statistically significant （P〉0.05）.② The differences of hs-CRP level and abnormal proportion among the three groups were statistically significant （F= 3.973, χ2 = 4.730, P〈 0.05）. The hs-CRP level in cerebrovascular accident group [（12.58±3.53） μg/mL] was higher than that in simple diabetes group [（4.87±1.94）μg/mL] and control group [（2.03±0.71）μg/mL], the differences were statistically significant （P〈0.05）. The hs-CRP level in simple diabetes group was higher than that in control group, the difference was statistically significant （P〈 0.05）. Conclusion The hs-CRP has significant predictive value in type 2 diabetes patients combined with cere-brovascular accident, it is a predictive factor of cerebrovascular accident.