细菌耐药性与抗菌药物使用及手卫生关系的研究!

目的：探讨细菌耐药性与住院患者抗菌药物使用强度及医务人员手卫生依从性之间的关系，为遏制细菌耐药性加剧及医院感染控制工作提供参考。方法收集2011年7月-2013年12月某院住院患者中分离的病原菌耐药率及同期住院患者中抗菌药物使用强度和医务人员手卫生依从率，并统计其数理相关关系。结果抗菌药物使用强度从73.6%持续下降到41.3%，医务人员手卫生依从率从25%左右持续提高到55%以上；同期细菌对部分抗菌药物耐药率与该抗菌药物使用强度相关系数r在0.332-0.924之间，与手卫生依从率相关系数r在-0.181--0.983之间。结论规范抗菌药物使用、落实包括手卫生在内的多重耐药菌隔离措施，显示出遏制细菌耐药性加剧的积极效果。

Analysis of the effect of antimicrobial drug use and hand hygiene to the bacterial resistance

Objective To preliminarily analyze the effect of antimicrobial drug use and the hand hygiene compliance of medical staff to the degrees of bacterial resistance and provide reference for clinical rational drug use and hospital in-fection control. Methods The statistics of the antibiotic resistance of pathogens, the intensity of use of antimicrobial a-gents, the hand hygiene compliance of the medical staff from July 2011 to December 2013 in a hospital, and their mathematical statistical correlations were conducted. Results During the study period, it was found that both the an-tibacterial use density of inpatients and the bacterial resistance of some pathogens continued to decline from 73.6 to 41.3, and the hand hygiene compliance rate of the medical staff continued to improve from 25% to 55% and above. In the same period, the bacterial resistances correlated the intensity of antimicrobial drug use and the hand hygiene com-pliance rates, and the correlation coefficients for r were among 0.332- 0.924 and-0.181 - -0.983 respectively. Con-clusion Comprehensive interventions can effectively reduce bacterial drug resistance, including regulating the use of antimicrobial agents, the implementation of multi-resistant isolation measures especially hand hygiene.