厚朴四君子汤颗粒治疗慢性胃炎的临床效果

目的 观察厚朴四君子汤颗粒治疗慢性胃炎的临床效果,旨在探讨其临床疗效和安全性。方法 选择深圳市南山区西丽人民医院2010年1月~2013年12月收治入院的慢性胃炎患者200例,随机分为两组,观察组和对照组,各100例。观察组采用自拟厚朴四君子汤加味治疗,对照组采用西药治疗。观察两组患者治疗2个疗程后临床综合疗效、中医证候疗效积分、血清胃泌素水平、黏膜病理组织学积分及安全性。结果 观察组治疗后临床治愈22例,好转72例,未愈6例,总有效率为94.0%。对照组治疗后临床治愈8例,好转64例,未愈28例,总有效率为72.0%。两组治疗后总有效率比较差异有统计学意义(χ2=5.254,P<0.05);两组患者治疗后各项临床症状积分与治疗前比较差异均有统计学意义(P<0.05);观察组治疗后胃脘或胁肋胀满、胃痛、口干、乏力、舌质、舌苔、嗳气及症状总积分与对照组治疗后比较差异均有统计学意义(P<0.05);两组患者治疗后组织病理学积分与治疗前比较差异均有统计学意义(P<0.05);观察组患者治疗后组织病理学积分与对照组治疗后比较差异有统计学意义(P<0.05);两组患者治疗后血清胃泌素水平与治疗前比较差异均有统计学意义(P<0.05);观察组患者治疗后血清胃泌素水平与对照组治疗后比较差异有统计学意义(P<0.05);观察组患者不良反应发生率为6.0%,对照组患者不良反应发生率为18.0%,两组患者不良反应发生率比较差异有统计学意义(χ2=4.256,P<0.05)。结论 厚朴四君子汤颗粒治疗慢性胃炎效果确切,值得临床进一步推广。

Clinical effect of Particles of Houpu Sijunzi Decoction in the treatment of chronic gastritis

Objective To observe the clinical effect of Particles of Houpu Sijunzi Decoction in the treatment of chronic gastritis, so as to evaluate the clinical efficacy and safety. Methods 200 cases of patients with chronic gastritis admit-ted to Xili People＆#39;s Hospital of Nanshan District in Shenzhen City from January 2010 to December 2013 were cho-sen and randomly divided into two groups, the observation group and the control group, with 100 cases in each group. The observation group was given self-made Particles of Houpu Sijunzi Decoction; the control group was treated by western medicine. After 2 courses of treatment, the clinical comprehensive therapeutic effect, TCM syndrome cura-tive effect score, serum gastrin level, Mucosal pathological integral and safety of the two groups were observed. Results After treatment in the observation group, 22 cases were cured, 72 cases were improved, 6 cases were ineffective, the total effective rate was 94%; in the control group, 8 cases were cured, 64 cases were improved, 28 cases were ineffec-tive, the total effective rate was 72%. The total effective rate of the two groups had a statistically significant difference （χ2=5.254, P 〈 0.05）; all of clinical symptoms scores after treatment of the two groups had statistically significant differences compared with before treatment （P〈0.05）;the epigastric or rib turgor, stomach pain, dry mouth, weakness, tongue nature, coated tongue, belching and total symptom scores after treatment in observation group had statistically significant differences compared with control group （P 〈 0.05）; pathological scores after treatment in two groups had statistically significant differences compared with before treatment （P〈 0.05）; pathological scores after treatment in observation group had statistically significant differences compared with control group （P 〈 0.05）; after treatment, the serum gastrin level had statistically significant differences compared with before treatment （P〈0.05）; the serum gas-trin lev