生物蛋白胶在未足月胎膜早破中的应用

目的:探讨生物蛋白胶封堵宫颈治疗未足月胎膜早破延长孕周的可行性和安全性.方法:收集我院2006年6月至2007年12月妊娠28～32周胎膜早破患者26例分成两组,治疗组13例采用生物蛋白胶封堵宫颈,对照组13例采用期待疗法,比较两组的延长孕周时间及围生儿结局.结果:治疗组无一例发生宫内感染和过敏反应.治疗组总有效率为61.5%,明显高于对照组(15.4%),P<0.05;治疗组较对照组延长孕周时间更长,新生儿死亡率、围生儿并发症发生率更低,两组比较差异有统计学意义(P<0.05).结论:生物蛋白胶应用于未足月胎膜早破可有效延长孕周时间,并且使用安全,无副反应.

Application of Fibrin Glue (FG) in Preterm Premature Rupture of Membranes

Objective:To probe into the feasibility and safety of extending the pregnancy period for pregnant women with preterm premature rupture of membranes(PPROM) by fibrin glue (FG). Methods:An investigation was made of 26 cases of PPROM from Jun 2006 to December 2007 in our Hospital. These 26 PPROM women were divided into two groups: study group treated by FG (13 cases), and expectant group without FG treatment (13 cases) as control. The extension of pregnant period and perinatal result were investigated. Results:There was no intraunterine infection and allergic response in study group. The total effective rate in FG group was 61.5%, higher than control group (15.4%) ( P<0.05); The FG group had a longer pregnant period,lower neonatal death and perinatal complication, when compare to control group ( P < 0.05). Conclusions: Fibrin glue can appropriately extend the pregnant period of women with PPROM.