Upregulation of the apoptosis regulators cFLIP,CD95 and CD95 ligand in peripheral blood mononuclear cells in relapsing-remitting multiple sclerosis |
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Authors: | Gomes Andreia C Jönsson Gun Mjörnheim Susanna Olsson Tomas Hillert Jan Grandien Alf |
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Affiliation: | Department of Neurology, Neurotec Department, Karolinska Institute at Huddinge University Hospital, R54, SE-141 86, Stockholm, Sweden. Andreia.Gomes@neurotec.ki.se |
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Abstract: | Multiple sclerosis (MS) is a chronic disease involving an inflammatory reaction within the white matter of the CNS, mediated by T cells, B cells and macrophages. The pathogenesis of MS may involve impaired activation-induced cell death of activated myelin-specific mature T cells. We investigated the mRNA expression of the apoptosis mediators cellular FLICE-inhibitory protein (cFLIP), caspase-8, CD95 and CD95L in peripheral blood mononuclear cells (PB MNCs) from MS patients using real-time PCR. The overall increased expression of the four key players in the CD95 pathway in relapsing-remitting MS suggests their involvement in the inflammatory process in this disease. |
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