Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B |
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Authors: | Hyo Jung Cho Soon Sun Kim Seun Joo Ahn Chang Bum Bae Han Gyeol Kim Young Jip Kim Seung Kyung Lee Ga Won Song Dong Joon Kim Seong Gyu Hwang Jin Mo Yang Young Bae Kim Young Nyun Park Sung Won Cho Jae Youn Cheong |
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Affiliation: | 1. Department of Gastroenterology, Ajou University School of Medicine, Suwon, South Korea;2. Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea;3. Department of Internal Medicine, CHA University College of Medicine, Sungnam, South Korea;4. Department of Internal Medicine, Catholic University College of Medicine, Suwon, South Korea;5. Department of Pathology, Ajou University School of Medicine, Suwon, South Korea;6. Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea |
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Abstract: | ObjectivesThe aim of this study was to determine the serum markers that predict significant inflammation in patients with chronic hepatitis B (CHB).Design and methodsBetween October 2005 and June 2009, 384 subjects with CHB were enrolled.ResultsMultiple logistic regression analysis identified the ALT, hyaluronic acid (HA) and procollagen III N-terminal peptide (PIIINP) as independent predictors of significant inflammation (grade ≥ 3). We constructed a formula for predicting significant inflammation. A significant inflammation (SI) score = 1.773 × ALT score + 1.599 × PIIINP score + 0.677 × HA score − 1.962. The area under receiver operating characteristic curve of the SI score was 0.831. The sensitivity, specificity, positive predictive value and negative predictive value of the SI score were 79.5%, 70.8%, 76.8% and 74.3%, respectively.ConclusionsA simple scoring system including ALT, PIIINP and HA is an accurate non-invasive predictor of significant inflammatory activities in patients with CHB. |
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Keywords: | Chronic hepatitis B Significant inflammation Serum marker Hyaluronic acid Procollagen III N-terminal peptide |
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