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| Promoter polymorphism of transforming growth factor-β1 gene and ulcerative colitis | |
| 引用本文： | Tamizifar B,Lankarani KB,Naeimi S,Rismankar Zadeh M,Taghavi A,Ghaderi A. Promoter polymorphism of transforming growth factor-β1 gene and ulcerative colitis[J]. World journal of gastroenterology : WJG, 2008, 14(2): 243-247. DOI: 10.3748/wjg.14.243 |
| 作者姓名： | Tamizifar B Lankarani KB Naeimi S Rismankar Zadeh M Taghavi A Ghaderi A |
| 作者单位： | Department of Internal Medicine Namazee Hospital Shiraz Iran,Department of Internal Medicine Namazee Hospital Shiraz Iran,Shiraz Institute of Cancer Research,School of Medicine Shiraz University of Medical Sciences,Shiraz Iran,Department of Internal Medicine Namazee Hospital Shiraz Iran,Department of Internal Medicine Namazee Hospital Shiraz Iran,Shiraz Institute of Cancer Research,School of Medicine Shiraz University of Medical Sciences,Shiraz Iran |
| 基金项目： | a grant from Shiraz University of Medical Sciences, No. 83-2363,a grant from Shiraz Institute for Cancer Research, ICR-8296 |
| 摘 要： | AIM： To elucidate the possible difference in two promoter polymorphisms of the transforming growth factor-β1 （TGF-β1） gene （-800G 〉 A, -509C 〉 T） between ulcerative colitis （UC） patients and normal subjects. METHODS： A total of 155 patients with established ulcerative colitis and 139 normal subjects were selected as controls. Two single nucleotide polymorphisms within the promoter region of TGF-β1 gene （-509C 〉 T and -800G 〉 A） were genotyped using PCR-RFLP. RESULTS： There was a statistically significant difference in genotype and allele frequency distributions between UC patients and controls for the -800G 〉 A polymorphism of the TGF-β1 gene （P 〈 0.05）. The frequency of the TGF-β1 gene polymorphism at position -800 showed that the AA genotype and the allele A frequencies significantly differed between the patients and healthy controls （P 〈 0.05）. At position -509, there was no statically significant difference in genotype and allele frequency between the patients and control subjects. CONCLUSION： The results of our study indicate that there is a significant difference in both allele and genotype frequency at position -800G 〉 A of TGF-β1 gene promoter between Iranian patients with UC and normal subjects. |
| 关 键 词： | 转移生长因子-β1 溃疡性结肠炎 基因多态性 基因治疗 |
| 收稿时间： | 2006-02-20 |
Promoter polymorphism of transforming growth factor-beta1 gene and ulcerative colitis |
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| Tamizifar B,Lankarani K B,Naeimi S,Rismankar Zadeh M,Taghavi A,Ghaderi A. Promoter polymorphism of transforming growth factor-beta1 gene and ulcerative colitis[J]. World journal of gastroenterology : WJG, 2008, 14(2): 243-247. DOI: 10.3748/wjg.14.243 | |
| Authors: | Tamizifar B Lankarani K B Naeimi S Rismankar Zadeh M Taghavi A Ghaderi A |
| Affiliation: | Department of Internal Medicine, Namazee hospital, Shiraz, Iran. |
| Abstract: | AIM: To elucidate the possible difference in two promoter polymorphisms of the transforming growth factor-beta1 (TGF-beta1) gene (-800G > A, -509C > T) between ulcerative colitis (UC) patients and normal subjects. METHODS: A total of 155 patients with established ulcerative colitis and 139 normal subjects were selected as controls. Two single nucleotide polymorphisms within the promoter region of TGF-beta1 gene (-509C > T and -800G > A) were genotyped using PCR-RFLP. RESULTS: There was a statistically significant difference in genotype and allele frequency distributions between UC patients and controls for the -800G > A polymorphism of the TGF-beta1 gene (P < 0.05). The frequency of the TGF-beta1 gene polymorphism at position -800 showed that the AA genotype and the allele A frequencies significantly differed between the patients and healthy controls (P < 0.05). At position -509, there was no statically significant difference in genotype and allele frequency between the patients and control subjects. CONCLUSION: The results of our study indicate that there is a significant difference in both allele and genotype frequency at position -800G > A of TGF-beta1 gene promoter between Iranian patients with UC and normal subjects. |
| Keywords: | Transforming growth factor-131 Ulcerative colitis Promoter Polymorphism Iran |
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