普罗布考、阿托伐他汀钙与阿司匹林合用对动脉粥样硬化的疗效

目的观察联合应用阿司匹林、阿托伐他汀钙、普罗布考对于动脉粥样硬化的疗效。方法观察90例缺血性脑血管病合并颈动脉粥样硬化患者,将其分为PAS治疗组30例,应用普罗布考、阿司匹林、阿托伐他汀钙;AS对照组30例,给予阿司匹林、阿托伐他汀钙(20 mg/d);A对照组30例仅给予阿司匹林。共随访3个月,分别在治疗前,治疗后3个月检测血脂及血清高敏C-反应蛋白(hs-CRP)。结果治疗后PAS治疗组及AS对照组总胆固醇、低密度脂蛋白胆固醇及hs-CRP含量均下降(P0.05),PAS治疗组更明显(P0.01)。结论阿司匹林、阿托伐他汀钙、普罗布考联合应用治疗动脉粥样硬化的调脂、降低炎症指标hs-CRP效果明显优于单用阿司匹林,也较阿司匹林、阿托伐他汀钙联用效果明显。

Therapeutic effect of combination therapy with probucol,atorvastatin calcium and aspirin on atherosclerosis

Objective To investigate the effects of combination therapy of probucol,atorvastatin calcium and aspirin drugs（PAS）of patients with atherosclerosis.Methods Ninety patients with ischemic cerebrvascular disease and carotid arteriosclerosis were randomized divided into three groups.Thirty cases in the treatment group PAS,were treated with probucol,atorvastatin calcium and aspirin,30 cases in the control group AS were treated with atorvastatin calcium and aspirin,while 30 cases in the control group A with aspirin alone.The serum lipids,high sensitivity C-reactive protein（hs-CRP） were measured before and three months after treatment.Results Serum total cholesterol,low density lipoprotein-cholesterol,hs-CRP levels in the treatment group PAS and in the control group AS were reduced compared with that of before treatment（P〈0.05）,especially in group PAS（P〈0.01）.Carotid plaques scrore was on a slight downward trend compared with that of before treatment（P〉0.05）.Conclusion Combination therapy of probucol,atorvastatin calcium and aspirin drugs can strengthen the effets on adjusting lipids and decreasing the level of inflammatory factor hs-CRP,furthermore the effects are stronger than that of combination therapy of probueol,atorvastatin calcium and that of monotherapy aspirin.