医用几丁糖预防手术后肠粘连的临床应用

摘要 目的：探索手术后使用医用几丁糖预防术后肠粘连的效果。 方法：应用计算机检索中国期刊全文数据库(CNKI：1989/2009)，由3位作者参与文献筛选、资料收集和质量评价，对符合纳入标准的研究对象进行比较几丁糖治疗组和未使用几丁糖的对照组在术后肠管通气时间及肠粘连的发生率的情况。 结果：共有15篇文献复合纳入标准，结果分析发现，应用几丁糖的患者肠管通气时间和术后肠粘连的发生率低于常规治疗组。 结论：应用医用几丁糖能明显减少肠粘连的发生率，缩短肠管通气时间，几丁糖能较好预防术后肠粘连及促进胃肠功能恢复。 关键词:几丁糖；肠粘连；预防；再手术；临床研究；生物材料 doi:10.3969/j.issn.1673-8225.2011.03.037

Clinical chitosan prevention against postoperative intestinal adhesions

Abstract OBJECTIVE: To explore the role of chitosan for the prevention of postoperative intestinal adhesion. METHODS: A computer-based online search of CNKI from 1989 to 2009 was conducted, three authors participated in the literature screening, data acquisition and quality evaluation. The intestinal ventilation time and the incidence of intestinal adhesion after surgery in chitosan-treated group and control group were compared in subjects met the inclusive criteria. RESULTS: Totally fifteen studies were in accordance with the inclusive criteria. Results showed that, the intestinal ventilation time and the incidence of intestinal adhesion rate post-operation in chitosan-treated group was significantly lower than routine treatment group. CONCLUSION: Chitosan can significantly reduce the incidence of intestinal adhesion rates and shorten intestinal ventilation time, chitosan can be well prevent intestine from adhesion after operation and promote gastrointestinal functional recovery.