罗汉果甜苷对大鼠慢性肝损伤保护作用的实验研究

目的:研究罗汉果甜苷(mogroside,Mog)对实验性慢性肝损伤的保护作用。方法:用CCl4建立大鼠慢性肝损伤模型,观察罗汉果甜苷对大鼠血清ALT、AST活性,肝组织SOD、GSH-Px活性及MDA含量的影响,观察罗汉果甜苷对肝组织病理变化的影响。结果:罗汉果甜苷可降低血清中ALT、AST活性;升高肝组织SOD、GSH-Px活性;降低肝组织MDA含量;明显减轻肝组织病理变化程度。与模型组相比有显著性差异(P<0.05或P<0.01)。结论:罗汉果甜苷对CCl4所致大鼠慢性肝损伤有明显的保肝作用,其机制可能与抑制脂质过氧化有关。

Experimental Study of Protective Effect of Mog on Chronic Liver Injury of Rats

Object: To study the Mog's protective effect on treating the chronic liver injury of rats. Methods: The rat model of chronic liver injury was prepared by CCl4 to observe the effects of Mog on the activities of ALT and AST, the activities of SOD and GSH-px in liver tissue, the content of MDA and the pathological changes of liver tissue. Results: Mog could significantly lower the ALT and AST activities in serum; promote the SOD and GSH-Px activities, decrease the content of MDA in liver tissue, and relieve the pathological changes of liver tissue significantly. Compared with the control group, there were significant differences (P<0.05 or P<0.01).Conclusion: Mog is shown to have striking protective effects on the CCl4-induced chronic liver injury in rats. Its mechanism may be related to inhibitory lipid peroxidation.