血清冠状病毒(变异株)特异性IgG抗体阳性患儿回顾性分析

目的　探讨儿童传染性非典型肺炎 (SARS)发生率低和症状轻的原因。方法　用酶联免疫吸附法 (ELISA)对2 0 0 1年及 2 0 0 3年 4～ 5月在首都儿科研究所门诊及住院的患儿血清标本 16 8份进行冠状病毒 (变异株 )特异性IgG抗体检测 ,并对住院患儿的临床表现进行回顾性分析。结果　 2 0 0 1年 77份血清标本 ,抗体阳性率为 4 1 6 % ;2 0 0 3年 4～ 5月 91份血清标本 ,阳性率为 39 6 %。对受检者中 10 2例曾经住院患儿临床表现的回顾性分析显示 ,抗体阳性与阴性患儿的临床表现及辅助检查结果无明显差别 ,抗体阳性患儿的临床诊断除肺炎外 ,还有上呼吸道感染、幼儿急疹、川崎病等。结论　冠状病毒 (变异株 )特异性IgG抗体阳性率有随年龄增长逐渐下降的趋势。在非SARS儿童中存在冠状病毒 (变异株 )特异性IgG抗体。

Retrospective investigation of children with SARS associate virus antibody positive

Objective To study why children with SARS have lower morbidity and mild symptoms.Methods ELSIA was used to detect the specific IgG antibody of SARS associated coronavirus in children in Beijing during 2001 and April to May in 2003.The clinical characteristics were compared between the two groups of children (divided by specific IgG antibody of SARS associated coronavirus).Results The positive rate of serum SARS coronavirus specific antibody was 41 56% in 77 children that were collected in 2001 year,and the positive rate was 39 56% in 91 children from April to May of 2003.Meanwhile the positive rate of adults was 0%.There was no significant difference between antibody positive or negative groups in terms of symptom,signs,total white blood cell count,and chest radiograph.Besides pneumonia,there were other diagnoses in the positive group,such as upper respiratory infection,mucocutaneous lymphnode syndrome and exanthema subitum.Conclusion The children not suffering from SARS have the specific antibody of SARS associate coronavirus.The antibody positive rate tends to decrease as children's age increases.