| 氨基葡萄糖分散片的处方优化及工艺考察 |
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| 引用本文： | 肖雷.氨基葡萄糖分散片的处方优化及工艺考察[J].安徽医药,2008,12(12):1142-1144. |
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| 作者姓名： | 肖雷 |
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| 作者单位： | 安徽医科大学第一附属医院药剂科,安徽,合肥,230061 |
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| 摘 要： | 目的优化氨基葡萄糖分散片的处方,研究其制备工艺。方法以崩解时限及溶出百分率为指标,采用正交试验筛选最佳处方和工艺。结果优选出最佳处方为：微晶纤维素（MCC）为填充剂,羧甲基淀粉钠（CMS-Na）和交联聚乙烯吡咯烷酮（PVPP）为崩解剂。结论本研究所制的分散片处方合理,产品质量稳定,溶出度较好,可供工业生产使用。
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| 关 键 词： | 分散片 正交试验 氨基葡萄糖 |
Preparation process of glucosamine sulfate dispersible tablets |
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| XIAO Lei.Preparation process of glucosamine sulfate dispersible tablets[J].Anhui Medical and Pharmaceutical Journal,2008,12(12):1142-1144. |
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| Authors: | XIAO Lei |
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| Institution: | XIAO Lei(1. Department of Pharmacy, First Affiliated Hospital of Anhai Medical University, Hefei 230061, China) |
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| Abstract: | Aim To investigate the optimum formulation and preparation process of glucosamine sulfate dispersible tablets. Methods The formula of glucosamine sulfate dispersible tablets was optimized in terms of dissolution percent by orthogonal design test. Results The tablets were prepared by moist granulation method with microcrystalling cellulose （MCC） as diluents, and the polyvinylpolyrrolidone （PVPP） and sodium starch glyeolate （CMS-Na） as disintegrant. Conclusion The formula of the dispersible tablets is reasonable,with faster disintegration and more complete dissolution. |
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| Keywords: | dispersible tablets orthogonal design glucosamine sulfate |
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