伊贝沙坦治疗高血压病66例疗效观察

目的观察伊贝沙坦对轻、中度高血压病患者疗效和耐受性。方法采用自身对照开放试验方法,观察符合诊断标准的66例高血压患者的血压。服用伊贝沙坦150 mg/d治疗,4周时测血压未达到显效标准则剂量增加1倍,即300 mg/d口服,总疗程8周。结果经4周治疗后,有48例(72.7%)用150 mg/d,18例(27.3%)用300 mg/d。其中显效54例(81.8%),有效7例(10.6%),总有效率92.4%。结论伊贝沙坦片对高血压病有良好的疗效,且耐受性好。

Clinical Observation of Patients with Hypertension Treated with Iribesartan

Objective To observe the efficacy and safety of iribesartan in treatment of patients with mild to moderate essential hypertension. Methods An open-label, self-controlled trial was conducted. 66 patients with mild to moderate essential hypertension were treated with oral irbesartan, 150 mg/d, and were given with 300 mg/d for 8 weeks if their blood pressure was not decreased effectively after 4 weeks. Results 48 patient＇s were received iribesartan 150 mg/d and the 18 were received irbesartan 300 mg/d. Four weeks later, the markedly effective rate was 81.8% （54 cases） ,the effective rate was 10.6% （7 cases） ,The total effective rate was 92.4%. The main adverse reactions of iribesartan were mild headache, dizziness and tiredness. Conclusion Iribesartan was effective and well tolerated for the patients with hypertension.