高脂血症痰瘀证候与胰岛素抵抗的关系

为了深入研究高脂血症痰瘀病理演变中胰岛素抵抗变化的特点,我们在临床计量辨证的基础上,进行了胰岛素敏感性指数及相关因素的检测及分析,报告如下.

Association Between Insulin Resistance and Phlegm Blood Stasis in Hperlipodemia

Objective:The purpose of this investigation was to explore the characteristics of insulin resistance existing in the pathological development of phlegm and blood stasis of hyper lipodemia.Method:All the patients of hyper lipodemia were divided into three group:35 cases of the syndrome of obstruction of the channels and collaterals from phlegm and blood stasis,33 cases of the syndrome of spleen asthenia with accumulation of phlegm and 29 cases of the syndrome of non phelgm and non blood stasis.At the same time 30 casses of normal group were observed.Then the integral of symptom and sign,fasting plasma glucose(FPG),fasting insulin(FINS),insulin sensitive index(ISI),insulin secretion function index(IS),lipid peroxide(LPO) and superoxide dismutase(SOD) were measured and done correlation analysis.Result:In both the syndrome of obstruction of the channels and collaterals from phlegm and blood stasis and the syndrome of spleen asthenia with accumulation of phlegm there was an increasing tendency of FPG,FINS,IS and LPO from the control group to non phelgm and non blood stasis to the syndrome of spleen asthenia with accumulation of phlegm to the syndrome of obstruction of the channels and collaterals from phlegm and blood stasis,but ISI and SOD decreased by turns.Simultaneously,there was obvious realation between the integral of symptom and sign of accumulation of phlegm and FPG or ISI(All P <0 05,0 01).However,the same association existed between the integral of symptom and sign of blood stasis and FINS or ISI(All P <0 05,0 01),in which the changes of ISI and the degree of correlation were more evident than the former.Conclusion:Insulin resistance has a certain effect on the the phthological development of phlegm and blood stasis.