Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms |
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Authors: | Tang Bo Cheng Gang Gu Jian-Chun Xu Cai-Hong |
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Institution: | Shenyang Pharmaceutical University, Shenyang City 110016, Liaoning Province, People's Republic of China. tangbobox@126.com |
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Abstract: | Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. Self-emulsifying drug delivery systems (SEDDS) are usually used to improve the bioavailability of hydrophobic drugs. Conventional SEDDS, however, are mostly prepared in a liquid form, which can produce some disadvantages. Accordingly, solid SEDDS (S-SEDDS), prepared by solidification of liquid/semisolid self-emulsifying (SE) ingredients into powders, have gained popularity. This article gives an overview of the recent advances in the study of S-SEDDS, especially the related solidification techniques and the development of solid SE dosage forms. Finally, the existing problems and the possible future research directions in this field are pointed out. |
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