盐酸羟考酮与硫酸吗啡治疗晚期癌痛的疗效观察

目的：探讨盐酸羟考酮与硫酸吗啡对晚期癌痛的疗效及安全性。方法：将120例晚期癌痛患者随机分为A、B两组,A组62例采用盐酸羟考酮进行治疗,B组58例采用硫酸吗啡进行治疗,两组均进行4周以上的疗效对比观察。结果：A组总有效率为93.5%,B组总有效率为91.4%,两组差异无统计学意义（P〉0.05）。两组治疗后生活质量均较治疗前明显改善（P〈0.05）。两组不良反应相似,但A组便秘较B组明显减少（P〈0.05）。结论：在治疗各种不同程度的癌痛时,盐酸羟考酮的镇痛效果比硫酸吗啡更有效,毒性反应更低,可作为吗啡的替代品,值得临床上进一步推广使用。

The effect observation of Oxycodone hydrochloride and Morphine sulfate in the treatment of cancer pain

Objective: To investigate the effect and safety of Oxycodone hydrochloride and Morphine sulfate in the treatment of cancer pain. Methods: One hundred and twenty cases of patients with cancer pain were randomly divided into group A and B, 62 cases of group A were given Oxycodone hydrochloride, 58 cases of group B were given Morphine sulfate, the effect of two groups in more than 4 weeks were observed. Results: The total effective rate of group A was 93.5%, and group B was 91.4%, the difference of two groups was not statistically significant (P>0.05). The life quality of two groups improved obviously after treatment (P<0.05). There were no serious adverse reactions in two groups, but the constipation of group A was lower than that of group B (P<0.05). Conclusion: In the treatment of various degrees of cancer pain, the analgesic effect of Oxycodone hydrochloride is more effective than Morphine sulfate, and can be used as substitute of Morphine sulfate, be worthy of further using.