Acute lymphoblastic leukemia with t(4;11) translocation after osteogenic sarcoma |
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| Authors: | J Kapelushnik I Dubé P Wilson M Greenberg |
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| Affiliation: | Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada. |
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| Abstract: | The authors report a case of acute lymphoblastic leukemia (ALL) with t(4;11) (q21;q23) occurring 9 months after treatment of osteogenic sarcoma. Cell surface marker and molecular analyses suggest early B lineage involvement. This is the first report, to the knowledge of the authors, of t(4;11) ALL arising after an osteogenic sarcoma. The observations of the authors support the possibility of a causal relationship between exposure to carcinogens and the occurrence of leukemia with t(4;11). |
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