Protective Effects of Lycopene against H2O2-Induced Oxidative Injury and Apoptosis in Human Endothelial Cells |
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| Authors: | XiangYu Tang XiangDong Yang YaFei Peng JunHua Lin |
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| Affiliation: | (1) Department of Cardiology, Union Hospital, Fujian Medical University and Fujian Provincial Institute of Coronary Disease, Fuzhou, Fujian, China, 350001;(2) Institute of cardiovascular Disease, University of South China, Hengyang, Hunan, China, 421001; |
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| Abstract: | Purpose Oxidative stress is considered to be a major factor contributing to damage of endothelial cells, and is an important component of the etiology of atherosclerosis. In this study, we investigated the effects of lycopene on the oxidative injury and apoptosis of endothelial cells induced by H2O2, and the effects of lycopene on the expression of p53, caspase-3 mRNA in injured cells. |
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