Immunodensity and mRNA expression of A2A adenosine,D2 dopamine,and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment |
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| Authors: | Leyre Urigüen M. Julia García-Fuster Luis F. Callado Benito Morentin Romano La Harpe Vicent Casadó Carmen Lluis Rafael Franco Jesús A. García-Sevilla J. Javier Meana |
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| Affiliation: | 1.Department of Pharmacology,University of the Basque Country,Leioa,Spain;2.Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM),http://www.cibersam.es;3.Laboratory of Neuropharmacology, IUNICS,University of the Balearic Islands,Palma de Mallorca,Spain;4.Red Temática de Investigación Cooperativa en Salud (Trastornos Adictivos),http://www.redrta.es/;5.Basque Institute of Legal Medicine,Bilbao,Spain;6.Centre Universitaire Romand de Médicine Légale-Site Genève, Faculté de Médecine,University of Geneva,Geneva,Switzerland;7.Institut d’Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Department of Biochemistry and Molecular Biology,University of Barcelona,Barcelona,Spain;8.Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED),http://www.ciberned.es/;9.The Molecular and Behavioral Neuroscience Institute,University of Michigan,Ann Arbor,USA |
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| Abstract: | Rationale Dopamine D2 receptors are the main target of antipsychotic drugs. In the brain, D2 receptors coexpress with adenosine A2A and CB1 cannabinoid receptors, leading to functional interactions. |
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