Radiofrequency ablation of early breast cancer followed by delayed surgical resection--a promising alternative to breast-conserving surgery |
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| Authors: | Ohtani Shoichiro Kochi Mariko Ito Mitsuya Higaki Kenji Takada Shinichi Matsuura Hiroo Kagawa Naoki Hata Sakae Wada Noriaki Inai Kouki Imoto Shigeru Moriya Takuya |
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| Affiliation: | aDepartment of Breast Surgery, Hiroshima City Hospital, 7-33 Moto-machi, Naka-ku, Hiroshima 730-8518, Japan;bDepartment of Pathology, Hiroshima City Hospital, 7-33 Moto-machi, Naka-ku, Hiroshima 730-8518, Japan;cKagawa Breast Clinic, 1–20 Mikawa-cho, Naka-ku, Hiroshima 730-0029, Japan;dDepartment of Pathology 2, Kawasaki Medical University, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan;eDepartment of Breast Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan;fDepartment of Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan;gDepartment of Breast Surgery, School of Medicine, Kyorin University, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan |
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| Abstract: | To examine the radiofrequency ablation (RFA) reliability in early breast cancer, we performed RFA followed by delayed surgical resection on 41 patients with invasive or non-invasive breast carcinoma less than 2 cm. MRI scans were obtained before ablation and resection. Excised specimens were examined pathologically by haematoxylin-eosin and nicotinamide adenine dinucleotide-diaphorase staining. 40 patients completed 1 RFA session, which was sufficient to achieve complete tumour cell death. Overall complete ablation rate was 87.8% (36/41). There were no treatment-related complications other than that of a superficial burn in 1 case. After RFA, the tumour was no longer enhanced on MRI in 25/26 (96.2%) cases. Residual cancer, which was suspected on MRI in 1 case, was confirmed pathologically. MRI could be an applicable modality to evaluate therapeutic effect. RFA could be an alternate local treatment option to breast-conserving surgery for early breast cancer. |
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| Keywords: | Radiofrequency ablation Early breast cancer Complete tumour cell death |
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