| 鞘内注射加巴喷丁和/或吗啡对切口痛大鼠脊髓氨基酸含量的影响 |
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| 引用本文： | 邹功胜,胡兴国,孔明,刘艳阳,范素贞,曾因明. 鞘内注射加巴喷丁和/或吗啡对切口痛大鼠脊髓氨基酸含量的影响[J]. 国际麻醉学与复苏杂志, 2009, 30(4): 332-334,372. DOI: 10.3760/cma.j.issn.1673-4378.2009.04.014 |
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| 作者姓名： | 邹功胜 胡兴国 孔明 刘艳阳 范素贞 曾因明 |
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| 作者单位： | 徐州医学院江苏省麻醉医学研究所&江苏省麻醉学重点实验室,221002;湖南省桃源县人民医院麻醉危重医学科;湖南衡阳南华大学附属第二医院麻醉科 |
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| 基金项目： | 江苏省级高校重点实验室开放课题 |
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| 摘 要： | Objective To study the effects of intrathecally administering gabapentin and/or morphine on the amino acid neurotransmitters in spinal cord of rat incision pain models.Methods Forty male SD rats were randomly divided into five groups (n=8) and were intrathecally inserted catheter.Paw incision models were made 5d later.Gabapentin (50 μg,group Ⅲ) or morphine(2.5 μg,group Ⅳ) or both (group Ⅴ) were intrathecally injected 30 min before incision.Another two groups were regarded as shame (group Ⅰ) or control (group Ⅱ).Pain behavior was determined 2 h later using mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL).The content of four amino acids including glutamate,aspartate,glycine and γ-aminobutyric acid in rat spinal cord were detected.Results MWT and TWL decreased and the content of glutamate and aspartate in spinal cord increased significantly 2 h after incision(P＜0.05)in groups Ⅱ,Ⅲ and Ⅳ (without statistically differences among three groups),but not in group Ⅴ,compared to them in group Ⅰ.There were no differences in the content of glycine and γ-aminobutyric acid in rat spinal cord 2 h after incision among four groups.Conclusion Intrathecal gabapentin significantly enhances the antinociceptive effect of intrathecal morphine in rat incision pain model,which may owe to the decreased level of excitatory amino acids in spinal cord.
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| 关 键 词： | 加巴喷丁 吗啡 氨基酸 脊髓 |
Effects of intrathecal gabapentin and/or morphine on amino acid neurotransmitters in spinal cord of rat incision pain models |
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| Abstract: | Objective To study the effects of intrathecally administering gabapentin and/or morphine on the amino acid neurotransmitters in spinal cord of rat incision pain models.Methods Forty male SD rats were randomly divided into five groups (n=8) and were intrathecally inserted catheter.Paw incision models were made 5d later.Gabapentin (50 μg,group Ⅲ) or morphine(2.5 μg,group Ⅳ) or both (group Ⅴ) were intrathecally injected 30 min before incision.Another two groups were regarded as shame (group Ⅰ) or control (group Ⅱ).Pain behavior was determined 2 h later using mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL).The content of four amino acids including glutamate,aspartate,glycine and γ-aminobutyric acid in rat spinal cord were detected.Results MWT and TWL decreased and the content of glutamate and aspartate in spinal cord increased significantly 2 h after incision(P＜0.05)in groups Ⅱ,Ⅲ and Ⅳ (without statistically differences among three groups),but not in group Ⅴ,compared to them in group Ⅰ.There were no differences in the content of glycine and γ-aminobutyric acid in rat spinal cord 2 h after incision among four groups.Conclusion Intrathecal gabapentin significantly enhances the antinociceptive effect of intrathecal morphine in rat incision pain model,which may owe to the decreased level of excitatory amino acids in spinal cord. |
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| Keywords: | GabapentinMorphineAmino acidSpinal cord |
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