| 健脾益气活血方对脾虚型血小板聚集缺陷症血浆糖盏蛋白含量的影响 |
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| 引用本文： | 沈 霖,张红星,杨胜兰,等. 健脾益气活血方对脾虚型血小板聚集缺陷症血浆糖盏蛋白含量的影响[J]. 中国中西医结合消化杂志, 2014, 0(2): 57-60 |
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| 作者姓名： | 沈 霖 张红星 杨胜兰 等 |
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| 作者单位： | [1] 华中科技大学协和医院中西医结合科,湖北武汉430022 [2] 武汉市第一医院中医科,湖北武汉430022 [3] 武汉市第三医院妇产科,湖北武汉430060 |
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| 基金项目： | 国家自然科学基金资助项目（No：81072945,81102692） |
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| 摘 要： | [目的]健脾益气活血方对脾虚型血小板聚集缺陷症糖盏蛋白(glycocalicin,GC)表达的影响,探讨其治疗该病的可能机制。[方法]127例脾虚型血小板聚集缺陷症患者随机分为中药组与西药组,中药组82例用健脾益气活血方治疗,西药组45例用安络血治疗,2组均治疗2个月;观察2组治疗后脾虚症状改善、止血疗效及血小板聚集恢复率;采用酶联免疫吸附法检测2组治疗前后及52例健康人(正常对照组)的血浆GC含量。[结果]中药组脾虚症状改善总有效率87.81%、西药组为64.44%,中药组止血总有效率为89.02%、西药组为37.78%,中药组血小板聚集功能恢复率64.63%、西药组仅4.44%;2组比较均差异有统计学意义(P0.01)。2组患者治疗前GC含量均高于正常对照组(P0.05);中药组治疗后患者的GC含量下降明显优于西药组(P0.05),与正常对照组比较差异无统计学意义(P0.05)。[结论]健脾益气活血方降低脾虚型血小板聚集缺陷症患者高于正常的GC含量,抑制GPⅠbα过度水解可能是其止血和恢复血小板聚集功能的疗效机制之一。
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| 关 键 词： | 血小板聚集缺陷 糖盏蛋白 脾虚 健脾益气活血方 |
Effect of prescription for invigorating spleen function reinforcing vital Qi and activating blood circulation on plasma levels of glycocalicin in patients with platelet aggregation defect of spleen deficiency syndrome |
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| SHEN Lin,ZHANG Hong-xing,YANG Sheng-lan,ZHAO C-uang,LING Jia-yan,YANG Yah-ping,SHUAI Bo. Effect of prescription for invigorating spleen function reinforcing vital Qi and activating blood circulation on plasma levels of glycocalicin in patients with platelet aggregation defect of spleen deficiency syndrome[J]. Chinese Journal of Integrated Traditional and Western Medicine on Digestion, 2014, 0(2): 57-60 |
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| Authors: | SHEN Lin ZHANG Hong-xing YANG Sheng-lan ZHAO C-uang LING Jia-yan YANG Yah-ping SHUAI Bo |
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| Affiliation: | 1Department of Integrated Traditional and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022,China; 2Department of Integrated Traditional Medicine, the First Hospital of Wuhan, Wuhan 430022, China; 3Department of Gynaecology and Obstetrics, the Third Hospital of Wuhan,Wuhan 430060,China) |
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