| Serum IL-10 Level in Allergic Rhinitis Patients and Its Effect on Serum Total IgE |
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| 作者姓名： | 刘光辉 祝戎飞 |
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| 作者单位： | Department of Allergy Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China，Department of Allergy Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China |
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| 摘 要： | disease.Itsepisodeisregulatedbymanykindsofcytokines.IL10isoneofthem,whichisanim portantnaturalimmuneregulatorandmainlypro ducedbyTh2cells.Itcaninhibittheantigen pres entingeffectsofmacrophagecellsandtheprolifer ationofactiveTcells,andsuppresstheintensityofinflammation1,2].ItalsoplaysanimportantroleintheproductionofimmunoglobulineE.ThisstudysurveyedthelevelsofserumIL10inallergicrhinitispatientstoinvestigateitsrolesinthepath ogenesisofallergicrhinitisanditscorrelationtotheserumtotalimmunoglu…
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| 关 键 词： | IL-10 血清 过敏性鼻炎 IgE 变态反应 |
| 收稿时间： | 2005-10-22 |
Serum IL-10 level in allergic rhinitis patients and its effect on serum total IgE |
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| Liu Guanghui,Zhu Rongfei.Serum IL-10 Level in Allergic Rhinitis Patients and Its Effect on Serum Total IgE[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2005,25(6):724-725. |
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| Authors: | Liu Guanghui Zhu Rongfei |
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| Institution: | Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | Summary To investigate the level of serum IL-10 in allergic rhinitis patients and the correlation between IL-10 and serum total IgE
(TIgE). 50 allergic rhinitis patients and 30 normal subjects were involved in the study. The levels of serum IL-10 and TIgE
were measured by enzyme-linked immunosorbent assay (ELISA), and the correlation between serum IL-10 and TIgE was analyzed.
In the allergic rhinitis group, the levels of serum IL-10 and TIgE were 8.34±2.48 pg/mL and 142.6±28.2 KUΛ/L. In the normal control group, they were 12.86±2.88 pg/mL and 47.2±12.2 KUΛ. There were significant differences between the two groups (P<0.01); and the level of serum TIgE in the patients was negatively correlated with that of IL-10 (r=−0.46,P=0.02). The level of serum IL-10 was significantly decreased in allergic rhinitis patients, which was beneficial to the synthesization
of IgE. IL-10 plays an important role in the episode of allergic rhinitis.
LIU Guanghui, male, born in 1952, Associate Professor |
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| Keywords: | allergic rhinitis IL-10 total IgE |
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