PTEN基因在膀胱移行细胞癌中的表达及意义

目的]研究第10号染色体丢失的张力蛋白同源的酪氨酸磷酸酶基因(phosphatase and tensin homology deleted on chromosome ten,PTEN)在膀胱移行上皮细胞癌(BTCC)组织中的表达水平及其与BTCC生物学行为的关系及临床意义.方法]以免疫组化SP法检测10例正常膀胱黏膜及69例BTCC组织中的PTEN基因的表达水平.结果]在10例正常膀胱组织中PTEN基因均表达阳性或强阳性.在69例BTCC组织中PTEN高表达组为46例(66.7%),其中阳性15例,强阳性31例.随着肿瘤分期、分级的增加PTEN表达显著减少(P＜0.01).结论]PTEN可能成为估计BTCC恶性程度及肿瘤侵袭性的一项有用的指标.

Expression and Significance of PTEN in Bladder Transitional Cell Carcinoma

Objective] To investigate the protein expression of the tumor suppressor gene PTEN(phosphatase and tensin homolog deleted on chromosome ten)gene and its relationship with biological behavior of bladder transitional cell carcinoma(BTCC),and its clinical value.Methods] Immunohistochemical method was used in detecting PTEN gene in 69 BTCC and 10 normal bladder tissues.Results] High expression of PTEN was found in all normal bladder tissues.The positive expression rate of PTEN gene in BTCC were 66.7%(46/69).Of 46 BTCC,15 was positive and 31 was strong positive.Significant differences existed in the expression of tumor suppressor gene between carcinomas form different pathological grades and clinical stages(P<0.05).Conclusion] The abnormal expression of PTEN gene may play an important role in the malignant progression and invasion of BTCC.