Quinacrine不同给药途径对家兔血药浓度的影响

目的　研究 quinacrine经不同途径给药的血药浓度 ,了解 quinacrine经阴道向子宫内给药绝育 (quinacrine女性非外科绝育法 )可能产生的毒副反应。方法　以兔为模拟对象 ,用荧光分析法分别测定宫腔内缓释给药、静脉、口服和输卵管内注射等 4种不同途径给quinacrine的血药浓度变化。结果　血药浓度峰值以静脉给药法最高 ,宫腔内缓释给药法最低。宫腔内缓释给药法的血药浓度水平接近其他给药方法血药浓度水平的残余浓度。血药浓度下降的起点静脉法在给药后立即产生 ,口服法在给药后 8h出现 ,输卵管内注射法见于给药后 4h ,而宫内缓释法则可维持到 7d。结论　从是否产生全身性的毒副反应的角度看 ,quinacrine宫腔内缓释给药法比口服法低 ,用于女性非外科手术绝育是安全的

Comparativestudy affecting plasma concentration of quinacrine by giving the drug in uterus and otherways

AIM　To study and investigate the side reactions of quinacrine given asfemale sterilization through uterus by observing the plasma concentrations of quinacrineas sterilization given through different ways. METHODS　Rabbits were taken as mock object. The plasma concentrations ofquinacrine given through uterus, vein, os, and injection in fallopian tube were determinedseparately with fluorescence analysis. RESULTS　The peak value of plasma concentration is the highest by iv, but isthe lowest by releasing slowly uterus. The plasma concentration level almost equates thesurplus plasma concentration of other groups. The starting point when plasma concentrationdecrease appears soon as the drug is given by iv, however it is seen after 8 h giving thedrug by per os, after 4 h by fallopian tube and after 7 h by releasing slowly in uterus. CONCLUSION　It is safe that quinacrine is used in no surgical femalesterilization through releasing slowly in uterus.