| 补体片段C_4d病理学研究进展 |
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| 引用本文： | 丁鑫,郑智勇,余英豪. 补体片段C_4d病理学研究进展[J]. 医学综述, 2008, 14(2): 188-190 |
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| 作者姓名： | 丁鑫 郑智勇 余英豪 |
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| 作者单位： | 1. 福建医科大学福总临床医学院,福州,350025;中国人民解放军南京军区福州总医院病理科,福州,350025
2. 中国人民解放军南京军区福州总医院病理科,福州,350025 |
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| 摘 要： | 补体片段C4d是补体成分C4裂解产物,主要参与补体经典途径的激活。在体液免疫反应中,C4d可以借共价键与血管内皮或基底膜结合并长期存在。因此C4d能够反应体液免疫反应的存在,尤其是在器官移植中反映排斥反应的存在。近年来C4d在病理学中应用研究方面又有了一些重要发现,如在自身免疫性疾病、淋巴瘤、妊娠性肾病诊断方面的应用。
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| 关 键 词： | 补体 C4d 病理学 器官移植 移植物排斥 |
| 文章编号： | 1006-2084（2008）02-0188-03 |
| 收稿时间： | 2007-05-02 |
| 修稿时间： | 2007-09-13 |
Pathological Study Progress of C4d |
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| DING Xin,ZHENG Zhi-yong,YU Ying-hao. Pathological Study Progress of C4d[J]. Medical Recapitulate, 2008, 14(2): 188-190 |
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| Authors: | DING Xin ZHENG Zhi-yong YU Ying-hao |
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| Affiliation: | DING Xin , ZHENG Zhi-yong, YU Ying-hao ( 1. Fuzong Clinical School of Fujian Medical University. Fuzhou 350025, China ; 2. Department of Pathology, Fuzhou General Hospital of Nanjing Military Command of PIA , Fuzhou 350025, China ) |
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| Abstract: | Complement C4d is a split product of complement C4,and mainly participate the activation of classical pathway of complement.In humoral immune reaction,C4d can combine with blood vessel endothelium or basement membrane by covalent bond,which can exist in long-term.C4d can reflect the existence of humoral immune reaction,especially the existence of reject reaction in organ transplantation.Recent years,there are other important findings of C4d about its application study in pathology,for example the application in the diagnosis of autoimmune diseases,lymphoma and gestational nephrosis. |
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| Keywords: | Complement C4d Pathology Organ transplant Graft rejection |
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