| 半数有效量在静脉麻醉剂药效学分析中的应用进展 |
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| 引用本文： | 梁超,郑宏.半数有效量在静脉麻醉剂药效学分析中的应用进展[J].国际麻醉学与复苏杂志,2007,30(1):255-257. |
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| 作者姓名： | 梁超 郑宏 |
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| 作者单位： | 新疆医科大学第一附属医院麻醉科,乌鲁木齐,830054; |
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| 摘 要： | 随着静脉麻醉剂药代、药效动力学研究的迅速发展,以及基于不同群体药代、药效动力学参数的靶控输注技术的日渐成熟.静脉麻醉剂半数有效量(CP50/EC50)在药效学分析起着重要的作用.此文综述了近年来CP50/EC50在常用静脉麻醉剂药效学分析中的应用进展,并对确定CPSO/EC50的方法学予以介绍和评价.
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| 关 键 词： | 半数有效量 静脉麻醉剂 序贯法 概率分析法 |
Progress in CP50/EC50 application in pharmacodynamic analysis of intravenous anesthetics |
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| LIANG Chao,ZHENG Hong.Progress in CP50/EC50 application in pharmacodynamic analysis of intravenous anesthetics[J].international journal of anesthesiology and resuscitation,2007,30(1):255-257. |
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| Authors: | LIANG Chao ZHENG Hong |
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| Abstract: | With the rapid advance in studies on pharmacokinetics and pharmacodynamics of intravenous anesthetics, and the maturation of target-controlled infusion technique based on different population pharmacokinetics and pharmacodynamics, CP50 and EC50 play more and more important roles in pharmacodynamic analysis. This article reviews the recent progress in CP50/EC50 ap-plication in pharmacodynamic analysis of commonly used intravenous anesthetics, introduces and evaluates the methods of CP50/ EC50 determination. |
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| Keywords: | CP50/EC50Intravenous anestheticsUp-and-down methodProbit method |
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