Mechanisms of bronchoconstriction and of thrombocytopenia induced by collagen in the guinea pig |
| |
Authors: | B B Vargaftig J Lefort D Joseph F Fouque |
| |
Institution: | 1. Centre de Recherche Merrell International, 16, rue d''Ankara, 67084, Strasbourg Cedex, France;2. Unité de Venins, Institut Pasteur, 28, rue du Doux, 75015, Paris, France |
| |
Abstract: | Collagen injected to guinea pigs i.v. increased the pulmonary resistance to inflation (bronchoconstriction) and induced thrombocytopenia. Immune platelet depletion protected against the effects of collagen, and has been shown not to prevent bronchoconstriction induced by the prostaglandin/thromboxane A2 precursor arachidonic acid. Use of inhibitors demonstrated that histamine, serotonin, acetylcholine and bradykinin were not involved with the effects of collagen in the guinea pig. Aspirin and indomethacin inhibited collagen-induced bronchoconstriction completely and thrombocytopenia partly, supporting the hypothesis that the former is prostaglandin cyclo-oxygenase dependent, whereas the latter has a thromboxane A2-independent mechanism as well. Carrageenan, heparin and reserpine inhibited the in vivo effects of collagen to various extents, but their precise mechanism of action could not be discovered. Collagen-induced bronchoconstriction is strictly platelet and thromboxane A2-dependent. |
| |
Keywords: | Anti-inflammatory drugs Coagulation Complement Platelets Thromboxane A2 Bronchoconstriction Collagen |
本文献已被 ScienceDirect 等数据库收录! |
|