产妇弓形虫感染对新生儿影响的研究

目的探讨孕妇弓形虫感染对胎儿的影响.方法采用酶免三联诊断法对356例母婴配对标本进行血清学检测.结果产妇弓形虫感染率平均为1 9.1%,各单项检测分别为CAg 15.2%、IgM 2.5%、IgG 3.4%;新生儿弓形虫感染率平均为17.7%,其脐血各单项检测分别为CAg 1 6.9%、IgM 0.3%、IgG 2.2%.CAg垂直传播率为35.2%(19/54),IgG垂直传播率为33.3%(4/12).在4例畸胎儿中,2例脐血弓形虫血清学阳性.结论孕妇感染弓形虫有1/3机会可通过胎盘垂直感染胎儿,影响胎儿发育,重者致畸、致死.

STUDY ON TOXOPLASMA GONDII INFECTION OF PARTURIENT WOMEN AND ITS EFFECTS ON NEW BORN INFANTS

Objective To explore the effects on new born infants after pregnant women infected with Toxoplasma gondii. Methods Matched blood samples were collected from 356 paired mothers and babies to detect the infection of T. gondii. An ELISA triple diagnostic reagent was used for the test of circulating antigen (CAg), antitoxoplasma antibodies IgM and IgG. Results The average infection rate of Toxoplasma in pregnant women was 19.1%, among them the positive rate of CAg, IgM and IgG was 16.9%, 0.3% and 2.2% respectively. From the matched infant samples, the proportion of vertical transmission of CAg was 35.2% (19/54) and IgG was 33.3% (4/12). The results indicated that near one third fetus were infected from their mothers before gave birth. 4 cases of congenital malformation were investigated, among them 2 serum samples were positive. Conclusion About one third fetus were able to get infection through placenta from their mothers which caused vertical transmission before gave birth and the development of fetus could be impaired even malformation and death.