Role of cholecystokinin in bombesin- and meal-stimulated pancreatic polypeptide secretion in dogs |
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Authors: | Jan B M J Jansen MD Alphons J L DE Jong MD Manfred V Singer MD Wolfgang Niebel MD Lucio C Rovati MD Prof Dr Cornelis B H W Lamers MD |
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Institution: | (1) Department of Gastroenterology and Hepatology, University Hospital, Building 1, C4-P015, P.O. Box 9600, 2300 RC Leiden, The Netherlands;(2) Division of Gastroenterology, Department of Medicine, University of Essen, FRG;(3) Rotta Research Laboratories, Monza, Italy |
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Abstract: | This study was undertaken to delineate the role of cholecystokinin (CCK) in bombesin- and meal-stimulated pancreatic polypeptide (PP) secretion in seven conscious dogs by studying: (1) the stimulatory effect of similar plasma levels of CCK induced by a meal and infusions of bombesin and the synthetic CCK analog cerulein on plasma PP, and (2) the inhibition of PP secretion by the CCK-receptor antagonist CR-1409 during these three stimuli. The stimulation of PP secretion during bombesin (11.0±1.6 nM/hr) and after the meal (8.9±2.0 nM/hr) were significantly (P<0.05) greater than during infusion of the CCK analog cerulein (2.7±0.4 nM/hr). CR-1409 significantly inhibited the bombesin- and meal-stimulated PP secretion to 2.0±0.4 nM/hr (81%; P<0.05) and 3.1±1.2 nM/hr (47%; P<0.05), respectively, while the cerulein-stimulated PP release was almost abolished to 0.2±0.1 nM/hr (93%; P<0.05) by the drug. These findings point to an important role for CCK in the regulation of bombesin- and meal-stimulated PP secretion.Supported by grant 13-37-43 from the Netherlands Foundation for Medical Research MEDIGON and grant Si 228/7-1 from the Deutsche Forschungsgemeinschaft. |
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Keywords: | bombesin cholecystokinin cerulein pancreatic polypeptide lorglumide CCK-receptor antagonist CR-1409 |
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