B型钠尿肽测定在心衰、高血压患者中的临床应用

目的探讨B型钠尿肽(BNP)在心力衰竭(简称心衰)、高血压患者中的应用价值。方法采用荧光免疫分析技术,对181例心衰患者、50例原发性高血压病患者及健康对照人群30例进行血浆BNP水平检测,同时以彩色多普勒超声心电动仪测定心衰患者左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF),并与BNP作相关性分析。结果心衰组患者血浆BNP水平高于高血压组,心衰组和高血压组均高于对照组,且差异有显著性(P<0.05～0.01)。BNP水平与LVEF、LVESD、LVEDD的数值具有相关性(r分别为-0.57、0.65和0.68,P<0.01)。结论BNP是反映心室功能的灵敏指标。

B-type natriuretic peptide in diagnosis of congestive heart heart failure and hypertension

Objective To evaluate the clinical value of B-type natriuretic peptide (BNP) in diagnosis of congestive heart failure and hypertension. Methods BNP level of plasma was measured by fluorescence immunoassay on congestive heart failure(CHF) group (181 cases), hypertension group (50 cases) and control group (30 cases), besides, LVEDD, LVESD and LVEF of CHF patients were taken by color doppler ultrasonograghy and analysis was done in relation with BNP. Results Plasma BNP level of CHF group was significantly higher than that of hypertension group and both of above mentioned groups, their BNP levels were higher than that of control group respectively (P<0.05- 0.01), BNP level among different groups, significant differrence was observed. There was obvious correlation between BNP level and the value of LVEF, LVESD and LVEDD (r was -0.57, 0.65 and 0.68 respectively, P<0.01). Conclusion BNP level is a sensitive index for verification of ventricle function.