内分泌治疗引起乳腺癌雌激素受体变化的初步探讨

本文对42例乳腺癌组织进行二次ER测定,并根据病人的月经状态不同,给予不同的性激素治疗,观察内分泌治疗对ER状态的影响及分型细胞中细胞的变化。本文认为采用细胞化学方法测定ER,简便易行,实用于临床。

Changes in estrogen receptors in patients with breast carcinoma under endocrine treatment

Fourty-two patients with breast carcinoma were operated. These were divided into an experimental aad a controlled group. The former was again divided into a premenopausal and a postmenopaupausal subgroup. Estrogen receptor (RE) assay was performed twice by using cytochemical method in all cases during hospitalization.Samples were obtained from the tumor with fine needle aspiration. Under fluorescent microscope the carcinoma cells were classified into 5types(A, B, C, D and E) . ER positive cases (type A+B+C) accounted for more than10%, otherwise the cases being ER negative. Testosterone propionate was successively given to patients in the premenopausal subgroup every day for a mean of 6.3days.ER positive rate was 52% (11/21)before and 38% (8/21) after eudocrine therapy respectively. Three (27%) of the ER positive cases changed into ER negative after endocrine therapy, although without statistical significance. The number of positive cells decreased and negative cells increased,with a statistical significance. Stilbestrol was successively given to the postmenopausal subgroup for a mean of 5.8 days.ER positive rate was 78% (7/9) .This and the number of positive cells showed no obvious change after endocrine therapy. In the controlled group no change in ER status or the number of positive cells was observed between the 2 ER assays.