血管内皮生长因子受体1及孕激素受体在子宫肌瘤中的表达

目的研究血管内皮生长因子受体1(VEGF-R1)、孕激素受体(PR)在子宫肌瘤组织中的表达及其相关性,探讨二者在子宫肌瘤发生发展中的作用。方法采用免疫组化的SP法,检测60例子宫肌瘤及肌瘤周围正常组织,正常子宫组织中PR及VEGFR1的表达,并用图象分析法测定二者的表达强度。结果60例子宫肌瘤组织中PR及VEG-FR1的表达阳性率分别为88·33%及75%,其表达均高于相应的瘤旁正常组织及正常子宫组织(P<0·01),相关性分析PR及VEGFR1表达之间存在明显关联性(P<0·01)。结论子宫肌瘤组织中PR及VEGFR1均高表达,说明二者均参与子宫肌瘤的发生发展。二者表达呈正相关,说明孕激素(P)与肌瘤内高浓度的孕激素受体(PR)结合可能通过诱导VEGF-R1的合成增加,使肌瘤血管内皮细胞对VEGF敏感性增强,促进肌瘤中血管生长,增加肌瘤血运,从而促进肌瘤生长并产生肌瘤的各种临床症状。

Expression of vascular endothelial growth Factor-receptor1 and progesteronez receptor in patient with uterine leiomyoma

Objective To investigate the expression of PR and VEGFR1 in Uterine Leiomyoma, the correlation between them, and their role in the pathogenesis and development of UL. Methods Sixty paraffin-embedded Uterine Leiomyoma samples and their controls were tested with using immunochemistry method. Results The positive rate of PR and VEGFR1 in 60 Uterine Leiomyoma were 88.33%, 75% respectively. Their expression in the groups of Uterine Leiomyoma were higher than that of the controls(P<0.01). Moreover, there was a close correlation between PR and VEGFR1 expression levels(P<0.01). Conclusion There are high PR and VEGFR1 expression in Uterine Leiomyoma. It is possible for VEGFR1 and PR were involved in the pathogenesis of UL. Progesterone may through progesterone-receptor promote the expression of VEGF-R1 in leiomyoma, which will make vascular endothelial cells were more sensitive to VEGF. So VEGFR1 and PR may play an important role in uterine leiomyoma enlargement.