Phylogenetic classification of Japanese mtDNA assisted by complete mitochondrial DNA sequences |
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Authors: | C Nohira S Maruyama K Minaguchi |
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Institution: | (1) Department of Forensic Odontology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba City 261-0011, Japan; |
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Abstract: | We investigated control and coding region polymorphisms in mitochondrial DNA (mtDNA) in 100 unrelated individuals from a Japanese
population and determined the basal phylogenetic haplogroup lineages in all samples under updated information. Many of the
basal phylogenetic haplogroup lineages assigned on East Asian mtDNA haplogroups corresponded to those previously established.
However, new haplogroup lineages such as M7a2a, M7a2b, M7a2*, M7c1b, M11b2*, G2b*, D4c1b1a, D4g2b, A4*, A9, N9b*, B4d1, B4d2,
and F1e were identified and established by complete sequencing. Although sequence comparison of the 1.15-kb control region
identified 84 mitochondrial haplotypes, examination of coding region polymorphisms increased the total number of haplotypes
to 91. Determination of the basal haplogroup lineages increased the discrimination power of mtDNA polymorphisms for personal
identification and their usefulness in determining geographic origin in forensic casework in Japanese and other East Asian
populations. |
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Keywords: | |
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