老年高血压患者降压治疗后24小时动态血压与心脑血管事件发生率的分析

目的分析老年高血压患者降压治疗后24h动态血压与心脑血管事件发生的情况,为临床降压治疗提供依据。方法将1074例患者分为两组,高血压组748例,非高血压组326例。采用24h动态血压监测技术监测血压,观察老年高血压患者降压治疗后心脑血管事件发生情况及其他相关指标。结果高血压组降压治疗后24h动态血压水平与非高血压组比较有显著差异(P<0.05),大部分患者血压控制良好,动态24h收缩压、舒张压平均值在正常范围,但均高于非高血压组;心脑血管事件发生率、有高血压家族史、吸烟、糖尿病、既往患有心脑血管病史等人数比率以及体重指数、左心室重量指数均显著高于非高血压组。结论高血压组较非高血压组更易发生心脑血管事件;脉压是其发生心脑血管事件的重要因素;应注意适度降压。

Analysis of the 24 h ambulatory blood pressure and occurrence of cardio-cerebral vascular events during antihypertensive treatment in geriatric patients

Objective To analyze the 24 h ambulatory blood pressure and occurrence of cardio-cerebral vascular events during the antihypertensive treatment in geriatric patients and provide clinical basis for antihypertensive therapy of hypertension.Methods 1 074 patients were divided into two groups(748 in hypertension group and 326 in non-hypertension group).Their information of 24 h ambulatory blood pressure,the occurrence of cardio-cerebral vascular events and other relative events during antihypertensive treatment were collected,and compared between the 2 groups.Results Although the 24 h systolic pressure,diastolic pressure and pulse pressure of the hypertensive patients were well controlled,their ambulatory blood pressure indexes were significantly higher than those in non-hypertensive group.In hypertensive patients,the incidence of cardio-cerebral vascular events,rates of family history of cardiovascular disease,smoking,diabetes mellitus and previous cardiovascular disease,and body mass index,left ventricle mass index were higher than those in non-hypertensive group.Conclusions Patients in hypertensive group are more liable to suffer from cardio-cerebral vascular events than those in normotensive group.Pulse pressure is a determinant factor for cardio-cerebral vascular events.Attention should be paid to the antihypertensive treatment.