Some further properties of human pulmonary mast cells recovered by bronchoalveolar lavage and enzymic dispersion of lung tissue |
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| Authors: | K. B. P. Leung K. C. Flint B. N. Hudspith J. Brostoff N. McI. Johnson K. Seager M. D. Hammond F. L. Pearce |
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| Affiliation: | (1) Department of Chemistry, University College London, 20 Gordon Street, WC1H 0AJ London, UK;(2) Department of Immunology, Middlesex Hospital Medical School, W1 London, UK;(3) The Medical Unit, Middlesex Hospital Medical School, W1 London, UK;(4) Miles Laboratories Ltd, Stoke Poges, Slough, UK |
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| Abstract: | The properties of human pulmonary mast cells obtained by bronchoalveolar lavage (BAL) and enzymic dispersion of lung tissue have been compared with those of basophil leucocytes. On challenge with anti-human IgE, the pulmonary cells released both histamine and the newly generated mediators prostaglandin D2 (PGD2) and leukotriene C4 (LTC4). In contrast, the blood leucocytes released histamine but very little leukotriene and no prostanoid. Interestingly, both basophil leucocytes and BAL cells released histamine spontaneously in a hyperosmolar environment whereas dispersed lung (DL) cells showed limited reactivity under these conditions. The possible clinical significance of these findings in human bronchial asthma is discussed. |
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