妊娠期营养素补充剂的使用对妊娠期妇女贫血状况影响的队列研究

  目的  探讨中国妊娠期妇女营养素补充剂的使用情况和妊娠合并贫血的关系。  方法  采用自行设计的妊娠期营养素补充剂使用情况调查问卷，对“中国孕产妇队列研究·协和”项目中的孕妇进行调查，随访收集研究对象营养素补充剂的使用情况和妊娠合并贫血的诊断情况，采用Logistic线性回归分析模型对数据进行关联性分析。  结果  共纳入研究对象3 321例。妊娠合并贫血的发生率为14.0%。Logistic线性回归分析模型结果显示，与全妊娠期使用叶酸的孕妇相比，未坚持全妊娠期使用叶酸的孕妇，更容易发生贫血(OR=1.362，95% CI:1.096~1.691, P=0.005)。  结论  未坚持全妊娠期使用叶酸是妊娠合并贫血的危险因素，应鼓励孕妇在全妊娠期持续地使用叶酸以降低贫血的发生风险。

Cohort study on the impact of nutrient supplement use during pregnancy on anemia in pregnant women

Objective To investigate the relationship between the use of nutrient supplements and anemia in pregnant women in China. Methods A self-designed questionnaire on the use of nutrient supplements during pregnancy was used on pregnant women in the Chinese Pregnant Women Cohort Study. The use of nutrient supplements and the diagnosis of anemia during pregnancy were followed up and the data were analyzed by Logistic liner regression model. Results A total of 3 321 subjects were included in the study. The incidence of anemia with pregnancy was 14.0%. The results of Logistic liner regression model showed that compared with the women who used folic acid throughout pregnancy, those who did not use folic acid throughout pregnancy were more likely to have anemia(OR=1.362, 95% CI: 1.096-1.691, P=0.005). Conclusions Failure in continuous use of folic acid throughout pregnancy is a risk factor for anemia in pregnancy. Pregnant women should be encouraged to use folic acid throughout pregnancy to reduce the risk of anemia.