SOFA评分联合PCT检测对脓毒症患者病情及其预后的临床评估价值

目的 动态观察序贯器官功能衰竭(sequential organ failure assessment,SOFA)评分、血清降钙素原(procalci-tonin,PCT)在脓毒症患者中的变化,分析两者联合检测对脓毒症患者病情及预后的评估.方法 选取2016年12月-2019年12月浙江大学医学院附属杭州市第一人民医院...

Clinical value of SOFA combined with procalcitonin test in assessing the condition and prognosis of patients with sepsis

Objective To observe the dynamic changes in sequential organ failure assessment(SOFA)scores and serum procalcitonin(PCT)in patients with sepsis and analyse the condition and prognosis of the patients through the combined assessment of the two tests.Methods Forty patients with sepsis who were admitted in the intensive care unit of Hangzhou City First People’s Hospital affiliated to Zhejiang University School of Medicine from December 2016 to December 2019 were included in this study.The patients were divided into sepsis and septic shock groups according to the severity of their illness and following the 2018 China sepsis/septic shock emergency treatment guidelines(2018).The patients were further divided into survival and death groups;the patients in the survival group were those that remained alive within 28 days of admission.SOFA scores and changes in PCT were compared by analysing area under the receiver-operating characteristic(ROC)curve.The predictive value of these scores and changes was used to assess the condition and prognosis of the patients.Results On the first and fifth days,differences in SOFA scores between the sepsis group and the septic shock group were statistically significant(all P<0.01).After the sepsis group was treated,the SOFA scores substantially improved,whereas PCT considerably decreased.On the fifth day,the SOFA score of the survival group(8.36±1.87)was lower than that of the death group(13.22±2.84),and the difference was statistically significant(P<0.01).Moreover,the PCT of the survival group was significantly different from that of the death group(P<0.01).ROC curve analysis revealed that the AUC of SOFA scores and PCT was 0.607 and 0.814,respectively.The combined AUC of SOFA scores and PCT was 0.875.Conclusion The combined test of SOFA and PCT can predict the condition and prognosis of sepsis patients.