Massive osteolysis in a girl with agenesis of thyroid C cells |
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Authors: | M Koršić Dražen Jelašić Kristina Potočki Zlatko Giljević Izet Aganović |
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Institution: | (1) Division of Endocrinology, Department of Medicine, University Hospital Rebro, Kišpatićeva 12, 10 000 Zagreb, Croatia,;(2) Department of Pathology, University Hospital Rebro, Zagreb, Croatia,;(3) Department of Radiology, University Hospital Rebro, Zagreb, Croatia, |
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Abstract: | A rare case of massive osteolysis affecting the pelvis of a young girl is presented. The clinical, radiographic, and histopathological
features are described in detail. Septicemia complicated the clinical course and the patient eventually died. Histopathological
examination of the pelvic lesion revealed massive osteolysis characterized by prominent osteoclastic activity with extensive
bone resorption. A thorough post-mortem histological examination of the thyroid gland showed no C cells. This is an interesting
observation, since it is known that thyroid C cells are the primary source of calcitonin. Since the main biological effect
of calcitonin is to inhibit osteoclastic bone resorption, there is a possibility that massive osteolysis in our case could
have been related to the lack of this hormone. There is a clear need for further investigation regarding the role of thyroid
C cells and calcitonin in this puzzling disease. |
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Keywords: | Massive osteolysis Gorham-Stout disease Radiography Histopathology Agenesis of thyroid C cells |
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