| 生长转化因子(TGF)基因型多态性与扩张型心肌病的相关研究 |
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| 引用本文： | 姜中影,孙明艳,孙政育,方胜,王春梅. 生长转化因子(TGF)基因型多态性与扩张型心肌病的相关研究[J]. 中国优生与遗传杂志, 2007, 15(10): 26-27 |
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| 作者姓名： | 姜中影 孙明艳 孙政育 方胜 王春梅 |
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| 作者单位： | 哈尔滨市第一医院血研所,黑龙江,150010 |
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| 摘 要： | 目的探讨中国北方地区汉族人生长转化因子(TGF)基因型别的多态性与扩张型心肌病(IDC)的相关性。方法对31例IDC患者采用顺序特异性引物-聚合酶链反应(PCR-SSP)方法检测TGF基因型别的多态性变化,并与35名健康献血者对照组进行对比分析。结果IDC组TGF(H)等位基因频率(38.71%)显著高于对照组(11.43%),P<0.05;提示该等位基因频率增高与IDC的发病相关;而TGF其它等位基因频率在IDC组和对照组中无明显差异。结论我国北方地区汉族人TGF(H)基因与IDC的易感性相关联。
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| 关 键 词： | 生长转化因子 扩张型心肌病 基因多态性 |
| 文章编号： | 1006-9534（2007）10-0026-02 |
| 收稿时间： | 2007-08-16 |
| 修稿时间： | 2007-08-16 |
The influence of TGF gene polymorphism on idiopathic dilated cardiomyopathy (IDC) |
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| JIANG Zhong-ying,SUN Ming-yan,SUN Zheng-yu,FANG Sheng,WANG Chun-mei. The influence of TGF gene polymorphism on idiopathic dilated cardiomyopathy (IDC)[J]. Chinese Journal of Birth Health & Heredity, 2007, 15(10): 26-27 |
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| Authors: | JIANG Zhong-ying SUN Ming-yan SUN Zheng-yu FANG Sheng WANG Chun-mei |
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| Affiliation: | Department of Hematology, The Harbin First Hospital, Heilongjiang 150001 |
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| Abstract: | Objective:To study the relationships between TGF genotype in Northern Chinese and idiopathic dilated cardiomyopathy(IDC). Methods : TGF genotypes polymor phism were analyzed by polymerase chain reaction-special sequence primer (PCR-SSP) in thirty-one idiopathic dilated cardiomyopathy(IDC) patients, and thirty-five controls. Results:The frequency of TGF (H) genotype was significantly higher in DCM patients than controls(P<0.05 .The TGF(H) genotype has significant influence on IDC.Conclusion:TGF(H) genotype in Northern Chinese positively related to IDC and most likely contributes to high risk for IDC. |
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| Keywords: | Idiopathic dilated cardiomyopathy(IDC) TGF genotypes polymorphism Cytokine |
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