应用多项肿瘤标记物检测卵巢恶性肿瘤的研究

目的为了提高卵巢恶性肿瘤诊断的特异性及敏感性,加强术后患者的病情追踪。我们应用５项肿瘤标记物ＳＡ,ＬＳＡ,ＣＡ１２５,ＣＰ２,６Ｂ１１Ａｂ２进行临床观察。方法对６７例卵巢恶性肿瘤及３３例卵巢良性肿瘤患者进行血清检测,以３８例正常妇女进行对照。结果单纯应用ＣＡ１２５诊断卵巢恶性肿瘤的敏感性及特异性分别为８３６％及８５９％,而５项肿瘤标记物中以任意３项及３项以上阳性为标记物诊断阳性时,检测卵巢恶性肿瘤的敏感性及特异性分别为８６６％及９４４％。临床Ⅰ、Ⅱ期患者的５项肿瘤标记物联合检测的特异性及敏感性,较ＣＡ１２５单项检测有明显提高。结论５项肿瘤标记物联合检测,对提高卵巢恶性肿瘤诊断的准确性及术后监测有一定意义

Application of multi-tumor markers in ovarian carcinoma

Objective To improve the specificity and sensitivity of diagnosis and to strengthen postoperative monitoring for patients with ovarian cancer. Methods Sera obtained from patients ovarian epithelial carcinoma (67 cases), benign ovarian tumor (33 cases) and from donor (38 cases) as control. Serologic examination of 5 tumor markers SA,LSA, CA 125 , CP 2, and 6B 11 Ab 2 was performed. Results The sensitivity and specificity in diagnosis of ovarian cancer were 83.6% and 85.9% respectively for CA 125 alone (>35 kU/L) whereas 86.6% and 94.4% respectively for multi tumor markers combined in which 3 or more indices showed positive. In addition, serial measurements of multi tumor markers have been done for 1 year after operation in 24 cases of ovarian epithelial carcinoma. The correlations between the levels of multi tumor markers either and the results of second look operation or and clinical manifestation of recurrence were analyzed. Conclusion Multi tumor markers exam ination could improve the diagnosis of ovarian cancer and early detection of recurrence.